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  • No : 3305
  • Date of Issue : 2020/11/13 10:18
  • Last Updated : 2020/12/02 08:55
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How to check for lens problems (LCMS)

How to check for lens problems (LCMS)
Category : 

Answer

As a result of contamination, it may not be possible to apply optimum voltage, which may decrease the ion transmittance. In addition, contamination of the multi pole outlet lens will cause charge-up, which will prevent ion transmission and will result in a significant decrease in sensitivity.
 
«Confirmation»
How to confirm that there is a significant decrease in sensitivity of low molecule components.
The sensitivity will be decreased from the lowmass side, and gradually advanced to the high mass side. If it is difficult to determine with real samples, confirm this with the standard sample in using the manual tuning.
In the example below, the peak intensity of the low-molecular-weight side (m / z168.10,256.15) is significantly degraded (1/100 or more). However, the peak intensity of the m / z1004.60 does not change by so much.
It is the sign of decrease in sensitivity due to contamination of the lens.
Click here for Manual Tuning.
 
«Corrective Actions»
Remove the lens system for cleaning.
Remove the skimmer from the Q array, and clean it by ultrasonic cleaning for 10 to 30 minutes. Wipe off the skimmer for cleaning. Clean the Multi pole by ultrasonic cleaning for 10 to 30 minutes. As for the lens, wiping the circumferential part of the hole using a lint-free cloth soaked in methanol after disassembling is more effective.
(Note: Do not disassemble any parts other than lens.)
(Note: Use methanol or isopropanol as cleaning solvent, and hexane for oil.)
Click here for Maintenance of the Lens System.

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